OPHTHALMIC NANOPARTICLES DRUG DELIVERY SYSTEMS
The present review details the latest development of nanoparticulate drug delivery systems, surface modification issues, drug loading strategies, release control and potential applications of nanoparticles. Preparation of nanoparticles Methods: Nanoparticles can be prepared from a variety of materials such as proteins, polysaccharides and synthetic polymers. The selection of matrix materials is dependent on many factors Including, Size of nanoparticles required.Inherent properties of the drug, e.g., aqueous solubility and stability.Surface characteristics such as charge and permeability.Degree of biodegradability, biocompatibility and toxicity. Drug release profile desired.Antigenicity of the final product.Methods: Dispersion of preformed polymersSolvent evaporation methodSpontaneous emulsification or solvent diffusionMethodPolymerization methodCoacervation or ionic gelation methodProduction of nanoparticles using supercritical fluid POLY METHYL METHACRYLATE (PMMA) (ACRYLIC) Structure of Polymethyl MethacrylateMolecular formula (C5O2H8)nINTRODUCTIONPoly (methyl methacrylate) (PMMA) poly (methyl 2-methylpropenoate) is a thermoplastic and transparent plastic. Chemically, it is the synthetic polymer of methyl methacrylate. PMMA is often used as an alternative to glass, and in competition with polycarbonate (PC). It is often preferred because of its moderate properties, easy handling and processing, and low cost, but behaves in a brittle manner when loaded, especially under an impact force. Acrylic, or acrylic fiber, can also refer to polymers or copolymers containing poly acrylonitrile.Pages: 1 2 [3] 4 5 6 7
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03.12.2009
5 Reasons a Commitment Phobic Man Falls Out Of Love & Leaves5 Reasons a Commitment Phobic Man Falls Out Of Love & LeavesAuthor: Albina FabianiAre you attracting Commitment Phobic Men? There are specific reasons why a man will make the conscious decision to commit to a woman - or not.Those reasons often have little or NOTHING to do with: 1) How long you've been together2) What everyone else, including you, thinks he "should do"3) How much you've "invested" in the relationshipA man will want to commit to you simply because of the way you make him FEEL.If he feels that his life will be better with you in it, than without you, he will want to commit to you. |
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