OPHTHALMIC NANOPARTICLES DRUG DELIVERY SYSTEMS
Fig.1 : Structure of a model drug-targeting nanoparticulate delivery system. Advantages of using nanoparticles as a drug delivery system include the following: Particle size and surface characteristics of nanoparticles can be easily manipulated to achieve both passive and active drug targeting after parenteral administration.They control and sustain release of the drug during the transportation and at the site of localization, altering organ distribution of the drug and subsequent clearance of the drug so as to achieve increase in drug therapeutic efficacy and reduction in side effects.Controlled release and particle degradation characteristics can be readily modulated by the choice of matrix constituents. Drug loading is relatively high and drugs can be incorporated into the systems without any chemical reaction; this is an important factor for preserving the drug activity.Site-specific targeting can be achieved by attaching targeting ligands to surface of particles or use of magnetic guidance.The system can be used for various routes of administration including oral, nasal, parenteral, intra-ocular etc. In spite of these advantages, nanoparticles do have limitations. For example, their small size and large surface area can lead to particleparticle aggregation, making physical handling of nanoparticles difficult in liquid and dry forms. In addition, small particles size and large surface area readily result in limited drug loading and burst release. These practical problems have to be overcome before nanoparticles can be used clinically or made commercially available.Pages: 1 [2] 3 4 5 6 7
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03.12.2009
The Good Side of Credit Cards (Ezine Ready)You have permission to publish this article electronically or in print, free of charge, as long as you leave the article title, author name, body and resource box in tact (means NO changes) with the links made active and you agree to our posted . Use the tools below to copy the article in plain text form, or you can copy it as HTML, ready to copy and paste directly into a web page. HTML Version: The Good Side of Credit Cards The Good Side of Credit Cards Author: Mitchel Crane You have long known the credit card. It is said to be your ultimate gear when you go shopping. |
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