OPHTHALMIC NANOPARTICLES DRUG DELIVERY SYSTEMS (Print Ready)

The selection of matrix materials is dependent on many factors Including, Size of nanoparticles required. Inherent properties of the drug, e.g., aqueous solubility and stability. Surface characteristics such as charge and permeability. Degree of biodegradability, biocompatibility and toxicity. Drug release profile desired. Antigenicity of the final product. Poly (methyl methacrylate) (PMMA) poly (methyl 2-methylpropenoate) is a thermoplastic and transparent plastic. Chemically, it is the synthetic polymer of methyl methacrylate. PMMA is often used as an alternative to glass, and in competition with polycarbonate (PC). It is often preferred because of its moderate properties, easy handling and processing, and low cost, but behaves in abrittle manner when loaded, especially under an impact force. Acrylic, or acrylic fiber, can also refer to polymers or copolymers containing poly acrylonitrile. The material was developed in 1928 in various laboratories and was brought to market in 1933 by Rohm and Haas Company. Plexiglas, Vitroflex, Limacryl, R-Cast, Per-Clax, Perspex, Plazcryl, Acrylex, Acrylite, Acrylplast, Altuglas, Polycast, Oroglass and Lucite and is commonly called acrylic glass, simply acrylic or plexiglas. PMMA is a glassy polymer with an amorphous structure. It has a density of 1.19 g/cm3 and has very low water absorption. The refractive index ranges from 1.49 to 1.51 depending on the type. Parts made of PMMA have high mechanical strength and good dimensional stability. PMMA is one of the hardest thermoplastics and is also highly scratch resistant. THERMAL, ELECTRICAL AND OPTICAL PROPERTIES Heat-stabilized types can withstand temperatures of up to 100oC.

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