OPHTHALMIC NANOPARTICLES DRUG DELIVERY SYSTEMS (Print Ready)
Kamal Singh Rathore1, S.S.Sisodia2, M.S.Ranawat2, R.K.Nema3 1B.N. Girls College of Pharmacy, Udaipur 2B.N. College of Pharmacy, Udaipur 3Rishiraj College of Pharmacy, Indore-MP Nanoparticles are defined as particulate dispersions or solid particles with a size in the range of 10-1000nm. The drug is dissolved, entrapped, encapsulated or attached to a nanoparticle matrix. Depending upon the method of preparation, nanoparticles, nanospheres or nanocapsules can be obtained. The major goals in designing nanoparticles as a delivery system are to control particle size, surface properties and release of pharmacologically active agents in order to achieve the site-specific action of the drug at the therapeutically optimal rate and dose regimen. Though liposomes have been used as potential carriers with unique advantages including protecting drugs from degradation, targeting to site of action and reduction toxicity or side effects, their applications are limited due to inherent problems such as low encapsulation efficiency, rapid leakage of water-soluble drug in the presence of blood components and poor storage stability. On the other hand, polymeric nanoparticles offer some specific advantages over liposomes. For instance, they help to increase the stability of drugs/proteins and possess useful controlled release properties. Fig.1 : Structure of a model drug-targeting nanoparticulate delivery system. Particle size and surface characteristics of nanoparticles can be easily manipulated to achieve both passive and active drug targeting after parenteral administration.
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